Abstract In this study, we conduct two-dimensional, axisymmetric simulations to investigate the growth and departure of a single bubble, with a particular focus on the conjugate heat transfer between the fluid and the heating wall. A multiscale modeling approach is employed to account for nanoscale effects near the liquid-vapor-solid triple contact line (CL). At the macro (bubble size) scale, the interface dynamics is captured with the front-tracking method by using the open-source code TRUST/TrioCFD. The macro scale algorithm is coupled with a sub-grid micro-region model. It is driven by the wall superheating at the CL as input, and predicts the macroscopic apparent contact angle and heat fluxes. To validate our modeling approach, we first conduct quantitative comparisons using the data on the bubble growth experiment RUBI and its simulations. Next, an investigation of the case of water under atmospheric pressure and gravity is performed. Notably, we observe a significant spatial variation in temperature near the nucleation site during the expansion and contraction of the bubble base. This variation greatly affects the thermal boundary layers in the fluid and solid domains and the bubble growth, demonstrating the need to resolve the conjugate heat transfer in the considered cases.