Lactate transporters in the rat barrel cortex sustain whisker-dependent BOLD fMRI signal and behavioral performance - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2021

Lactate transporters in the rat barrel cortex sustain whisker-dependent BOLD fMRI signal and behavioral performance

Résumé

Significance For decades, it was claimed that glucose was the sole and sufficient energy substrate to sustain neuronal activity and brain function. Our results challenge this view by demonstrating that despite glucose availability, lactate shuttling from astrocytes to neurons via monocarboxylate transporters is necessary to give rise to the blood oxygen level-dependent signal (used as a surrogate marker for activation) in the rat cerebral cortex following whisker stimulation. Moreover, lactate shuttling turned out to be also essential for sustaining behavioral performance associated with activation of the rat barrel cortex. These findings call for a reappraisal of neuroenergetics and the role of astrocytes in determining brain activation and function.
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hal-04632204 , version 1 (04-07-2024)

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Hélène Roumes, Charlotte Jollé, Jordy Blanc, Imad Benkhaled, Carolina Piletti Chatain, et al.. Lactate transporters in the rat barrel cortex sustain whisker-dependent BOLD fMRI signal and behavioral performance. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (47), pp.e2112466118. ⟨10.1073/pnas.2112466118⟩. ⟨hal-04632204⟩
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