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Article Dans Une Revue Thorax Année : 2023

Patients’ perceptions on clinical trials outcomes in pulmonary arterial hypertension therapy

Vicky Mai
Camille Gosselin
  • Fonction : Auteur
Élodie Tremblay
  • Fonction : Auteur
Gabrielle Rompré
  • Fonction : Auteur
Annie Christine Lajoie
  • Fonction : Auteur
Jason Weatherald
  • Fonction : Auteur
Sébastien Bonnet
  • Fonction : Auteur
Steeve Provencher

Résumé

The value placed by patients and their caregivers on the components of composite outcomes in pulmonary arterial hypertension (PAH) remains unknown. We surveyed the importance of these outcomes from a patients’ and caregivers’ perspective, with participants (n=335, including 257 patients with PAH) rating individual components defining clinical worsening in PAH trials as of critical, major, mild-to-moderate or minor importance. Most outcomes were considered of major or mild-to-moderate importance to patients. Death was the only outcome considered of critical importance. Perceptions of clinical outcomes varied between patients and caregivers. Integrating patients’ perception in the elaboration of clinical trials is essential.
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Dates et versions

hal-04627735 , version 1 (27-06-2024)

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Citer

Vicky Mai, Camille Gosselin, Élodie Tremblay, Gabrielle Rompré, Annie Christine Lajoie, et al.. Patients’ perceptions on clinical trials outcomes in pulmonary arterial hypertension therapy. Thorax, 2023, 78 (7), pp.721-725. ⟨10.1136/thorax-2022-219490⟩. ⟨hal-04627735⟩
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