Article Dans Une Revue International Journal of Infectious Diseases Année : 2024

Humoral response after mRNA COVID-19 primary vaccination and single booster dose in people living with HIV compared to controls: a French nationwide multicenter cohort study - ANRS0001s COV-POPART

1 F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC)
2 VBIC - Virulence Bactérienne et Infections Chroniques
3 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
4 VRI - Vaccine Research Institute [Créteil, France]
5 CHU Henri Mondor [Créteil]
6 UB - Université de Bordeaux
7 UMS 54 MART - Methods and Applied Research for Trial [UNIV Bordeaux]
8 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
9 CIRI - Centre International de Recherche en Infectiologie
10 HCL - Hospices Civils de Lyon
11 CHU - Hôpital Archet 2 [Nice]
12 UniCA - Université Côte d'Azur
13 CHU Angers - Centre Hospitalier Universitaire d'Angers
14 CIC 1415 - Centre d’Investigation Clinique [CHRU Tours]
15 APHM - Assistance Publique - Hôpitaux de Marseille
16 CHU Montpellier = Montpellier University Hospital
17 CIC Montpellier
18 BC2M - Biocommunication en Cardio-Métabolique
19 BPH - Bordeaux population health
20 CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux
21 CHUGA - CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble
22 CIC Grenoble - Centre d'Investigation Clinique [Grenoble]
23 Service des Maladies Infectieuses et Tropicales [Brest]
24 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
25 CHU Saint-Antoine [AP-HP]
26 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
27 CIC - Centre d'Investigation Clinique [Rennes]
28 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
29 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
30 UM - Université de Montpellier
31 CHU Pitié-Salpêtrière [AP-HP]
32 Le Trait d'Union, centre de soins de l'infection par le VIH [CHU Strasbourg]
33 Hôpital Foch [Suresnes]
34 ANRS - MIE - ANRS - Maladies infectieuses émergentes
35 HEGP - Hôpital Européen Georges Pompidou [APHP]
36 UVE - Unité des Virus Emergents
37 SISTM - Statistics In System biology and Translational Medicine
Aurelie Portefaix
Xavier de Lamballerie

Résumé

Background - This study aimed to compare the humoral responses to mRNA COVID-19 vaccination in people living with HIV (PWH) and HIV-negative individuals. Methods - We included PWH with an undetectable viral load under ART and HIV-negative participants from the French nationwide ANRS COV-POPART cohort who had received two doses of vaccine as a primary vaccination. We compared humoral response between controls and PWH, stratified by CD4 cell count (<200/mm and ≥200/mm CD4 cell counts) at 1, 6, and 12 months after primary vaccination. Results - A total of 1776 participants were included in this analysis, 684 PWH (99% were on ART, median CD4 counts 673 cells/mm) and 1092 controls. At 1 month, after adjustment on age, sex, and BMI, PWH had lower seroneutralization titers than controls, and PWH with <200 CD4 cell/mm had lower anti-Spike SARS-CoV-2 IgG antibodies. Same results were found at 6 months. However, in participants who received a booster dose between 6 and 12 months postprimary vaccination, we did not observe differences between PWH and controls at 12 months. Conclusion - PWH had high responses to primary mRNA COVID-19 vaccination. In those who received a booster dose after 6 months, the humoral response at 12 months increased to similar levels to controls, even in those with low CD4 counts at baseline.

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hal-04627501 , version 1 (27-06-2024)

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Paul Loubet, Jean-Daniel Lelievre, Alexis Francois, Elisabeth Botelho-Nevers, Christian Chidiac, et al.. Humoral response after mRNA COVID-19 primary vaccination and single booster dose in people living with HIV compared to controls: a French nationwide multicenter cohort study - ANRS0001s COV-POPART. International Journal of Infectious Diseases, 2024, 146, pp.107110. ⟨10.1016/j.ijid.2024.107110⟩. ⟨hal-04627501⟩
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