[Pharmacokinetic risk factors of beta-blockers overdose in the elderly: Case report and pharmacology approach]. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Annales de Cardiologie et d'Angéiologie Année : 2018

[Pharmacokinetic risk factors of beta-blockers overdose in the elderly: Case report and pharmacology approach].

Facteurs de risque pharmacocinétiques de surdosage en bêta-bloquants chez les patients âgés : cas clinique et rationnel pharmacologique

Résumé

Beta-blockers are widely prescribed in elderly patients and may induce severe adverse drug reactions. We report a case of bisoprolol-induced bradycardia in an elderly patient with impaired renal function and use of cytochrome P450 inhibitors. A literature review has been performed in order to analyze pharmacokinetic risk factors of beta-blockers overdosing in geriatrics. Various mechanisms can result in decreased elimination of beta-blockers. These mechanisms vary according to the beta-blocker agent and may be combined in some individuals, especially elderly patients. This can lead to unexpected overexposure. Knowledge about drug interactions and pharmacokinetic elimination pathways is important for preventing overexposure and adverse drug reactions when using beta-blockers.
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Dates et versions

hal-04627209 , version 1 (27-06-2024)

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Citer

L. Lafarge, L. Bourguignon, N. Bernard, T. Vial, M.-J. Dehan-Moya, et al.. [Pharmacokinetic risk factors of beta-blockers overdose in the elderly: Case report and pharmacology approach].. Annales de Cardiologie et d'Angéiologie, 2018, 67 (2), pp.91-97. ⟨10.1016/j.ancard.2018.02.001⟩. ⟨hal-04627209⟩
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