Identification of Cytochrome P450-Mediated Drug–Drug Interactions at Risk in Cases of Gene Polymorphisms by Using a Quantitative Prediction Model

The magnitude of drug-drug interactions mediated by cytochrome P450 (CYP) may depend on the genotype of polymorphic cytochromes. The objective of this study was to identify drug-drug interactions with greater magnitude in CYP variant groups than in extensive metabolizers.

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Pharmacologie

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https://hal.science/hal-04627208

Soumis le : jeudi 27 juin 2024-12:54:37

Dernière modification le : samedi 29 juin 2024-03:16:15

Dates et versions

hal-04627208 , version 1 (27-06-2024)

Identifiants

HAL Id : hal-04627208 , version 1
DOI : 10.1007/s40262-018-0651-8
PUBMED : 29572664

Citer

Nicolas Fermier, Laurent Bourguignon, Sylvain Goutelle, Nathalie Bleyzac, Michel Tod. Identification of Cytochrome P450-Mediated Drug–Drug Interactions at Risk in Cases of Gene Polymorphisms by Using a Quantitative Prediction Model. Clinical Pharmacokinetics, 2018, 57 (12), pp.1581-1591. ⟨10.1007/s40262-018-0651-8⟩. ⟨hal-04627208⟩

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