A Generic Model for Quantitative Prediction of Interactions Mediated by Efflux Transporters and Cytochromes: Application to P-Glycoprotein and Cytochrome 3A4 - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Clinical Pharmacokinetics Année : 2018

A Generic Model for Quantitative Prediction of Interactions Mediated by Efflux Transporters and Cytochromes: Application to P-Glycoprotein and Cytochrome 3A4

Résumé

The In Vivo Mechanistic Static Model (IMSM) is a powerful method used to predict the magnitude of drug-drug interactions (DDIs) mediated by cytochromes. The objective of this study was to extend the IMSM paradigm to DDIs mediated by efflux transporters and cytochromes.

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Pharmacologie
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Dates et versions

hal-04627173 , version 1 (27-06-2024)

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Citer

Michel Tod, Sylvain Goutelle, N. Bleyzac, L. Bourguignon. A Generic Model for Quantitative Prediction of Interactions Mediated by Efflux Transporters and Cytochromes: Application to P-Glycoprotein and Cytochrome 3A4. Clinical Pharmacokinetics, 2018, 58 (4), pp.503-523. ⟨10.1007/s40262-018-0711-0⟩. ⟨hal-04627173⟩
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