Intra-individual Pharmacokinetic Variability of Intravenous Busulfan in Hematopoietic Stem Cell-Transplanted Children - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Clinical Pharmacokinetics Année : 2020

Intra-individual Pharmacokinetic Variability of Intravenous Busulfan in Hematopoietic Stem Cell-Transplanted Children

Résumé

Busulfan therapeutic drug monitoring (TDM) is necessary to better achieve the target exposure in children before hematopoietic stem cell transplantation (HSCT). However, TDM-based dosing may be challenging if intra-individual pharmacokinetic variability (also denoted inter-occasion variability [IOV]) occurs during therapy.

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Pharmacologie
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Dates et versions

hal-04627001 , version 1 (27-06-2024)

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Hanen Marsit, Michaël Philippe, Michael Neely, Teresa Rushing, Yves Bertrand, et al.. Intra-individual Pharmacokinetic Variability of Intravenous Busulfan in Hematopoietic Stem Cell-Transplanted Children. Clinical Pharmacokinetics, 2020, 59 (8), pp.1049-1061. ⟨10.1007/s40262-020-00877-z⟩. ⟨hal-04627001⟩
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