Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested caseu2013control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue EBioMedicine Année : 2024

Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested caseu2013control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)

1 CIRC - IARC - Centre International de Recherche contre le Cancer - International Agency for Research on Cancer
2 CESP - Centre de recherche en épidémiologie et santé des populations
3 IGR - Institut Gustave Roussy
4 University of Oxford
5 TAU - Tel Aviv University
6 IBB - Institute of Biomathematics and Biometry - Helmholtz Zentrum München
7 NUS - National University of Singapore
8 University of Ljubljana
9 Aarhus University [Aarhus]
10 Aarhus University Hospital
11 UCPH - University of Copenhagen = Københavns Universitet
12 UniFI - Università degli Studi di Firenze = University of Florence = Université de Florence
13 Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
14 DIfE - German Institute of Human Nutrition Potsdam-Rehbrücke
15 University of Potsdam = Universität Potsdam
16 ISPRO - Istituto per lo studio, la prevenzione e la rete oncologica = Institute for Cancer Research, Prevention and Clinical Network
17 Human Tumor Immunobiology Unit [Fondazione IRCCS Istituto Nazionale dei Tumori, Milan]
18 "Federico II" University of Naples Medical School
19 Pediatric Hematology, University Hospital Città della Salute e della Scienza
20 CPO Piemonte - Centro di Riferimento per l'Epidemiologia e la Prevenzione Oncologica in Piemonte = Center for Cancer Prevention-Piemonte
21 ICO - Catalan Institute of Oncology = Instituto Catalán de Oncología
22 La Salle [Ramon Llull University]
23 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
24 Umeå University, Sweden
25 Imperial College London
26 University of Utah
27 Huntsman Cancer Institute [Salt Lake City]
Maria Jose Sánchez
  • Fonction : Auteur
Amaia Aizpurua Atxega
  • Fonction : Auteur
Alicia K. Heath
Scott A. Summers

Résumé

Background: Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain. Methods: In a caseu2013control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined associations between pre-diagnostic circulating concentrations of 97 lipid metabolites (acylcarnitines, glycerophospholipids and sphingolipids) and colorectal cancer risk. Circulating lipids were measured using targeted mass spectrometry in 1591 incident colorectal cancer cases (55% women) and 1591 matched controls. Multivariable conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between concentrations of individual lipid metabolites and metabolite patterns with colorectal cancer risk. Findings: Of the 97 assayed lipids, 24 were inversely associated (nominally p < 0.05) with colorectal cancer risk. Hydroxysphingomyelin (SM (OH)) C22:2 (ORper doubling 0.60, 95% CI 0.47u20130.77) and acylakyl-phosphatidylcholine (PC ae) C34:3 (ORper doubling 0.71, 95% CI 0.59u20130.87) remained associated after multiple comparisons correction. These associations were unaltered after excluding the first 5 years of follow-up after blood collection and were consistent according to sex, age at diagnosis, BMI, and colorectal subsite. Two lipid patterns, one including 26 phosphatidylcholines and all sphingolipids, and another 30 phosphatidylcholines, were weakly inversely associated with colorectal cancer. Interpretation: Elevated pre-diagnostic circulating levels of SM (OH) C22:2 and PC ae C34:3 and lipid patterns including phosphatidylcholines and sphingolipids were associated with lower colorectal cancer risk. This study may provide insight into potential links between specific lipids and colorectal cancer development. Additional prospective studies are needed to validate the observed associations. Funding: World Cancer Research Fund (reference: 2013/1002); European Commission (FP7: BBMRI-LPC; reference: 313010).
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hal-04626837 , version 1 (17-07-2024)

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Rhea Harewood, Joseph A. Rothwell, Jelena Bešević, Vivian Viallon, David Achaintre, et al.. Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested caseu2013control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). EBioMedicine, 2024, 101, pp.105024. ⟨10.1016/j.ebiom.2024.105024⟩. ⟨hal-04626837⟩
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