To create a new conceptual model of resilience based on evidence, this integrative systematic review aims to identify the evidence-based protective factors related to resilience among children, adolescents and young adults at-risk of several exposures. An Integrative Systematic review was conducted by using systematic principles according to PRISMA statement. Searching strategy was conducted through MEDLINE, CINAHL, Web of Science (ISI) and PsycINFO during July 2021(1991-2021). Keywords were related to resilience, self-esteem, hardiness, ego-resilience, risk factors, vulnerability, protective factors, ecological model and theoretical model. Those statiscally significant protective factors found in individual studies conducted with young populations (from 7 to 24 years old) exposed to violence, trauma or socio-economic instability were included in the qualitative synthesis. Of 15,235 peer-reviewed articles initially identified, 93 articles were screened and met the inclusion criteria; finally, 31 articles were included for the quality synthesis. More than 60 protective factors were found. They were classified in 10 different domains and two dimensions of resilience (Individual skills and Environmental), developing a new model of resilience: The Individual and Environmental Resilience Model (IERM). The Environmental dimension includes the domains: Family, School, Peers, Cultural and Community and The Individual skills dimension: Biological, Behaviour, Communications, Cognitive and Emotional domains. These domains and their specific protective factors have been set up as protective factors that significantly buffer negative outcomes in the face of adverse events. Compared with other models currently available, the new IERM model is potentially a more comprehensive approach that may facilitate the development of effective interventions to promote resilience in children, adolescents and young adults.