Squalamine: An Appropriate Strategy against the Emergence of Multidrug Resistant Gram-Negative Bacteria? - Archive ouverte HAL
Journal Articles PLoS ONE Year : 2008

Squalamine: An Appropriate Strategy against the Emergence of Multidrug Resistant Gram-Negative Bacteria?

Chanaz Salmi
  • Function : Author
Celine Loncle
  • Function : Author
Nicolas Vidal
  • Function : Author
Yves Letourneux
  • Function : Author
Jacques Fantini
  • Function : Author
Jean-Marie Pagès
  • Function : Author
Jean Michel Brunel
  • Function : Author

Abstract

We reported that squalamine is a membrane-active molecule that targets the membrane integrity as demonstrated by the ATP release and dye entry. In this context, its activity may depend on the membrane lipid composition. This molecule shows a preserved activity against bacterial pathogens presenting a noticeable multi-resistance phenotype against antibiotics such as polymyxin B. In this context and because of its structure, action and its relative insensitivity to efflux resistance mechanisms, we have demonstrated that squalamine appears as an alternate way to combat MDR pathogens and by pass the gap regarding the failure of new active antibacterial molecules.
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hal-04621000 , version 1 (22-06-2024)

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Chanaz Salmi, Celine Loncle, Nicolas Vidal, Yves Letourneux, Jacques Fantini, et al.. Squalamine: An Appropriate Strategy against the Emergence of Multidrug Resistant Gram-Negative Bacteria?. PLoS ONE, 2008, 3 (7), pp.e2765. ⟨10.1371/journal.pone.0002765⟩. ⟨hal-04621000⟩
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