Electromagnetic fluctuation-induced forces between atoms and surfaces are generally known as Casimir–Polder interactions. The exact knowledge of these forces is rapidly becoming important in modern experimental set-ups and for technological applications. Recent theoretical and experimental investigations have shown that such an interaction is tunable in strength and sign, opening new perspectives to investigate aspects of quantum field theory and condensed-matter physics. In this chapter we review the theory of fluctuation-induced interactions between atoms and a surface, paying particular attention to the physical characterization of the system. We also survey some recent developments concerning the role of temperature, situations out of thermal equilibrium, and measurements involving ultra-cold atoms.