Isolated liver involvement in Langerhans cell histiocytosis: A case reportLocalisation hépatique isolée d une histiocytose langerhansienne : à propos d un cas - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Annales de Pathologie Année : 2024

Isolated liver involvement in Langerhans cell histiocytosis: A case reportLocalisation hépatique isolée d une histiocytose langerhansienne : à propos d un cas

Résumé

© 2023 Elsevier Masson SASLangerhans cell histiocytosis (LCH) is a disease whose physiopathology remains unclear, involving both inflammatory processes and clonal proliferation. It is observable at any given age, although about ten times more frequent in children than adults. Hepatic involvement is not rare, mostly part of a systemic disease, and linked to a poor prognosis. We report here a case of LCH with solitary hepatic involvement in a 74 year-old patient. This case demonstrated molecular anomaly of the MAPK pathway, BRAF N486_P490del. Through this observation, we precise the epidemiological and histological aspects and diagnostic criteria of this rare disease.
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hal-04615208 , version 1 (18-06-2024)

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Pierre Allaume, Bruno Turlin, Eric Meneyrol, Gontran Bernard, Pauline Houssel-Debry, et al.. Isolated liver involvement in Langerhans cell histiocytosis: A case reportLocalisation hépatique isolée d une histiocytose langerhansienne : à propos d un cas. Annales de Pathologie, 2024, 44 (1), pp.69-74. ⟨10.1016/j.annpat.2023.12.001⟩. ⟨hal-04615208⟩
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