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Article Dans Une Revue Neurology Neuroimmunology & Neuroinflammation Année : 2024

PET Study of Microglial Activation in Kleine-Levin Syndrome

Anis Krache
Alexandre da Costa
Anne-Sophie Salabert

Résumé

Objectives: Kleine-Levin syndrome (KLS) is a rare recurrent hypersomnolence disorder associated with cognitive and behavioral disturbances, of unknown origin, but inflammatory mechanisms could be involved. We aimed to explore in vivo microglia activation using [18F]DPA-714 PET imaging in patients with KLS compared with controls, and during symptomatic vs asymptomatic periods. Methods: Patients with KLS and controls underwent a standardized clinical evaluation and PET imaging, using a radiolabeled ligand specific to the 18 kDa translocator protein. Images were processed on the PMOD (peripheral module) interface using a standard uptake value (SUV). Five regions of interest (ROIs) were analyzed: hypothalamus, thalamus, frontal area, cerebellum, and whole brain. SUV ratios (SUVr) were calculated by normalizing SUV with cerebellum uptake. Results: Images of 17 consecutive patients with KLS (7 during episodes, 10 out of episodes) and 14 controls were analyzed. We found no SUV/SUVr difference between KLS and controls, between patients in and out episodes in all ROIs, and no correlation between SUVr and episode duration at the time of PET scan. No association was found between SUVr and sex, disease duration, or orexin levels. Discussion: Our findings do not support the presence of neuroinflammation in KLS. Further research is needed to identify relevant biomarkers in KLS.
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hal-04615146 , version 1 (15-07-2024)

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Lucie Barateau, Anis Krache, Alexandre da Costa, Michel Lecendreux, Sofiene Chenini, et al.. PET Study of Microglial Activation in Kleine-Levin Syndrome. Neurology Neuroimmunology & Neuroinflammation, In press, 11 (4), pp.e200263. ⟨10.1212/NXI.0000000000200263⟩. ⟨hal-04615146⟩
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