Synthesis of highly functionalized spirooxindole derivatives via multicomponent [3+2] cycloaddition reactions - Archive ouverte HAL Accéder directement au contenu
Chapitre D'ouvrage Année : 2024

Synthesis of highly functionalized spirooxindole derivatives via multicomponent [3+2] cycloaddition reactions

Résumé

This book chapter describes recent advances in the synthesis of N-heterocycle-fused spirooxindole scaffolds via multicomponent [3+2] cycloaddition reactions via two different synthetic approaches. The first strategy involves in situ formation of isatin/3-aminooxindole-based azomethine ylides and their subsequent [3+2] cycloaddition with various activated alkenes. The second one employs 3-ylideneoxindoles as dipolarophiles with in situ formed 1,3-dipoles. In addition, mechanistic insights into these reaction and biological investigations of synthesized spirooxindoles have been discussed.

Domaines

Chimie
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Dates et versions

hal-04613842 , version 1 (17-06-2024)

Identifiants

Citer

Sarra Boudriga, Amani Toumi, Michael Knorr. Synthesis of highly functionalized spirooxindole derivatives via multicomponent [3+2] cycloaddition reactions. Kalim Deshmukh; Vraj R. Shah; Vraj R. Shah; Kalim Deshmukh. Spirooxindole Chemistry, Synthesis, Characterization and Biological Significance, Elsevier, pp.129-180, 2024, 978-0-443-22324-2. ⟨10.1016/B978-0-443-22324-2.00006-0⟩. ⟨hal-04613842⟩
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