Synthesis of highly functionalized spirooxindole derivatives via multicomponent [3+2] cycloaddition reactions
Résumé
This book chapter describes recent advances in the synthesis of N-heterocycle-fused spirooxindole scaffolds via multicomponent [3+2] cycloaddition reactions via two different synthetic approaches. The first strategy involves in situ formation of isatin/3-aminooxindole-based azomethine ylides and their subsequent [3+2] cycloaddition with various activated alkenes. The second one employs 3-ylideneoxindoles as dipolarophiles with in situ formed 1,3-dipoles. In addition, mechanistic insights into these reaction and biological investigations of synthesized spirooxindoles have been discussed.