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Article Dans Une Revue Scientific Reports Année : 2016

Serological and molecular epidemiology of canine adenovirus type 1 in red foxes (Vulpes vulpes) in the United Kingdom

David Walker
  • Fonction : Auteur
Seán Fee
  • Fonction : Auteur
Gill Hartley
  • Fonction : Auteur
Jane Learmount
  • Fonction : Auteur
Maria O’hagan
  • Fonction : Auteur
Anna Meredith
  • Fonction : Auteur
Barend de C. Bronsvoort
  • Fonction : Auteur
Thibaud Porphyre
Colin Sharp
  • Fonction : Auteur
Adrian Philbey
  • Fonction : Auteur

Résumé

Abstract Canine adenovirus type 1 (CAV-1) causes infectious canine hepatitis (ICH), a frequently fatal disease which primarily affects canids. In this study, serology (ELISA) and molecular techniques (PCR/qPCR) were utilised to investigate the exposure of free-ranging red foxes ( Vulpes vulpes ) to CAV-1 in the United Kingdom (UK) and to examine their role as a wildlife reservoir of infection for susceptible species. The role of canine adenovirus type 2 (CAV-2), primarily a respiratory pathogen, was also explored. In foxes with no evidence of ICH on post-mortem examination, 29 of 154 (18.8%) red foxes had inapparent infections with CAV-1, as detected by a nested PCR, in a range of samples, including liver, kidney, spleen, brain, and lung. CAV-1 was detected in the urine of three red foxes with inapparent infections. It was estimated that 302 of 469 (64.4%) red foxes were seropositive for canine adenovirus (CAV) by ELISA. CAV-2 was not detected by PCR in any red foxes examined. Additional sequence data were obtained from CAV-1 positive samples, revealing regional variations in CAV-1 sequences. It is concluded that CAV-1 is endemic in free-ranging red foxes in the UK and that many foxes have inapparent infections in a range of tissues.

Dates et versions

hal-04612762 , version 1 (14-06-2024)

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Citer

David Walker, Seán Fee, Gill Hartley, Jane Learmount, Maria O’hagan, et al.. Serological and molecular epidemiology of canine adenovirus type 1 in red foxes (Vulpes vulpes) in the United Kingdom. Scientific Reports, 2016, 6 (1), pp.36051. ⟨10.1038/srep36051⟩. ⟨hal-04612762⟩
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