A hollow-core fiber based stand-alone multimodal (2-photon, 3-photon, SHG, THG) nonlinear flexible imaging endoscope system - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue IEEE Journal of Selected Topics in Quantum Electronics Année : 2024

A hollow-core fiber based stand-alone multimodal (2-photon, 3-photon, SHG, THG) nonlinear flexible imaging endoscope system

Résumé

Multimodal nonlinear endoscopes have been a topic of intense research over the past two decades, enabling sub-cellular and label-free imaging in areas not reachable with table-top microscopes. They are sophisticated systems that can be implemented on an optical table in a lab environment, but they cannot be easily moved within or out of the lab. We present here a multimodal and flexible nonlinear endoscope system able to perform two-photon excited fluorescence and second harmonic generation imaging with a stand-alone and movable kart integrating a compact ultrashort laser source. In addition, the system can perform three-photon excited fluorescence and third harmonic generation imaging thanks to a delivery optical fiber that connects a large frame laser system to the stand-alone kart. The endoscopic fiber probes and delivery optical fibers are based on functionalized negative curvature hollow core fibers. The endoscope distal head has a diameter < 2.2 mm and can perform nonlinear imaging at max 10 frames/s over a field of view up to 600 μm with a ∼ 1 μm spatial resolution.
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Dates et versions

hal-04608983 , version 1 (12-06-2024)

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Dylan Septier, G. Brévalle-Wasilewski, Eloïse Lefebvre, N. Gajendra Kumar, Y. Wang, et al.. A hollow-core fiber based stand-alone multimodal (2-photon, 3-photon, SHG, THG) nonlinear flexible imaging endoscope system. IEEE Journal of Selected Topics in Quantum Electronics, inPress, ⟨10.1109/JSTQE.2024.3411821⟩. ⟨hal-04608983⟩
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