Unlicensed/Off-Label Drug Prescriptions at Hospital Discharge in Children: An Observational Study Using Routinely Collected Health Data - Archive ouverte HAL Access content directly
Journal Articles Healthcare Year : 2024

Unlicensed/Off-Label Drug Prescriptions at Hospital Discharge in Children: An Observational Study Using Routinely Collected Health Data

Elham Jaberi
Inesse Boussaha
  • Function : Author
Xavier Dode
Guillaume Grenet
Kim An Nguyen
  • Function : Author
  • PersonId : 1390361
  • IdHAL : nguyenan

Abstract

Background: Unlicensed and off-label (UL/OL) prescriptions have been associated with an increased risk of drug-related problems. Data of their prevalence at hospital discharge remain insufficient. We aimed to describe the prevalence of UL/OL drugs in outpatient prescriptions at discharge in children. Methods: We conducted a retrospective study using the routinely collected health data of children at discharge from 2014 to 2016. The primary reference source for determining licensed labelling was the summaries of product characteristics (SPCs) in a French industry-independent formulary named Thériaque. We described the characteristics of UL/OL prescriptions at discharge and looked for predictors of UL/OL prescriptions. Results: We included 2536 prescriptions of 479 children. Licensed, OL, and UL prescriptions accounted for 58.6% (95% CI: 56.7–60.5), 39.2% (95% CI: 37.3–41.1), and 2.3% (95% CI: 1.7–2.9), respectively. A total of 323 (74%) children received at least one UL/OL drug. Among the licensed drugs, bronchodilators (8.8%) and analgesics (8.6%), and among the OL drugs, antibiotics (2.8%), were the most prescribed. The younger age of the children and higher number of drugs they received increased the probability of UL/OL prescriptions (unadjusted p-value of ≤0.05). Conclusion: The prevalence of UL/OL prescriptions is about 40% at discharge from a pediatric university hospital in France.

Dates and versions

hal-04606188 , version 1 (09-06-2024)

Identifiers

Cite

Elham Jaberi, Inesse Boussaha, Xavier Dode, Guillaume Grenet, Behrouz Kassai, et al.. Unlicensed/Off-Label Drug Prescriptions at Hospital Discharge in Children: An Observational Study Using Routinely Collected Health Data. Healthcare, 2024, 12 (2), pp.208. ⟨10.3390/HEALTHCARE12020208⟩. ⟨hal-04606188⟩
0 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More