Use of MALDI-TOF mass spectrometry to monitor solid-phase synthesis of oligonucleotides - Archive ouverte HAL
Article Dans Une Revue Analytical and Bioanalytical Chemistry Année : 2002

Use of MALDI-TOF mass spectrometry to monitor solid-phase synthesis of oligonucleotides

Résumé

MALDI-TOF mass spectrometry has been used to characterize solid-supported oligonucleotides containing natural and non-natural and non-nucleoside moieties and a variety of internucleosidic linkages including phosphate and phosphite triesters and H-phosphonate diesters. This technique was used to follow the reactions involved in oligonucleotide synthesis; this enabled direct control of the elongation and optimization of the coupling process.
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Dates et versions

hal-04600638 , version 1 (04-06-2024)

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T Guerlavais, Albert Meyer, Francoise Debart, J-L Imbach, François Morvan, et al.. Use of MALDI-TOF mass spectrometry to monitor solid-phase synthesis of oligonucleotides. Analytical and Bioanalytical Chemistry, 2002, 374 (1), pp.57-63. ⟨10.1007/s00216-002-1395-7⟩. ⟨hal-04600638⟩
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