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Article Dans Une Revue OncoImmunology Année : 2022

Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice

Résumé

Writing in Science, Al Habsi et al. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in aged patients.
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hal-04596717 , version 1 (31-05-2024)

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Francesca Castoldi, Guido Kroemer, Federico Pietrocola. Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice. OncoImmunology, 2022, 11 (1), pp.2146855. ⟨10.1080/2162402X.2022.2146855⟩. ⟨hal-04596717⟩
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