Multiomics insights on the onset, progression, and metastatic evolution of breast cancer - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Frontiers in Oncology Année : 2023

Multiomics insights on the onset, progression, and metastatic evolution of breast cancer

Résumé

Breast cancer is the most common malignant neoplasm in women. Despite progress to date, 700,000 women worldwide died of this disease in 2020. Apparently, the prognostic markers currently used in the clinic are not sufficient to determine the most appropriate treatment. For this reason, great efforts have been made in recent years to identify new molecular biomarkers that will allow more precise and personalized therapeutic decisions in both primary and recurrent breast cancers. These molecular biomarkers include genetic and post-transcriptional alterations, changes in protein expression, as well as metabolic, immunological or microbial changes identified by multiple omics technologies (e.g., genomics, epigenomics, transcriptomics, proteomics, glycomics, metabolomics, lipidomics, immunomics and microbiomics). This review summarizes studies based on omics analysis that have identified new biomarkers for diagnosis, patient stratification, differentiation between stages of tumor development (initiation, progression, and metastasis/recurrence), and their relevance for treatment selection. Furthermore, this review highlights the importance of clinical trials based on multiomics studies and the need to advance in this direction in order to establish personalized therapies and prolong disease-free survival of these patients in the future.
Fichier principal
Vignette du fichier
10758476.pdf (2.93 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04596709 , version 1 (31-05-2024)

Identifiants

Citer

Lucia Alvarez-Frutos, Daniel Barriuso, Mercedes Duran, Mar Infante, Guido Kroemer, et al.. Multiomics insights on the onset, progression, and metastatic evolution of breast cancer. Frontiers in Oncology, 2023, 13, pp.1292046. ⟨10.3389/fonc.2023.1292046⟩. ⟨hal-04596709⟩
6 Consultations
5 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More