Fusion energy is a promising, safe, and reliable green energy solution to the increasing energy demand. However, there are several materials challenges that need to be overcome to increase the technical readiness to a level that enables a fusion pilot plant on the grid. This focus issue aims to identify and address a set of such key impediments for realizing deuterium-tritium (D–T) fusion power in a tokamak reactor and highlight the most recent progress on those research frontiers. The main emphasis of this collection is on materials development challenges resulting from helium irradiation, neutron-induced degradation, thermomechanical loading, and the corrosive environment faced by the divertor and first-wall materials, commonly known as plasma-facing components, and blanket systems for tokamak fusion reactors.