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Article Dans Une Revue (Article De Synthèse) JACS Au Année : 2022

New Benchmark in DNA-Based Asymmetric Catalysis: Prevalence of Modified DNA/RNA Hybrid Systems

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By harnessing the chirality of the DNA double helix, chemists have been able to obtain new, reliable, selective, and environmentally friendly biohybrid catalytic systems with tailor-made functions. Nonetheless, despite all the advances made throughout the years in the field of DNA-based asymmetric catalysis, many challenges still remain to be faced, in particular when it comes to designing a “universal” catalyst with broad reactivity and unprecedented selectivity. Rational design and rounds of selection have allowed us to approach this goal. We report here the development of a DNA/RNA hybrid catalytic system featuring a covalently attached bipyridine ligand, which exhibits unmatched levels of selectivity throughout the current DNA toolbox and opens new avenues in asymmetric catalysis.
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hal-04592516 , version 1 (24-06-2024)

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Nicolas Duchemin, Sidonie Aubert, João de Souza, Lucas Bethge, Stefan Vonhoff, et al.. New Benchmark in DNA-Based Asymmetric Catalysis: Prevalence of Modified DNA/RNA Hybrid Systems. JACS Au, 2022, 2 (8), pp.1910-1917. ⟨10.1021/jacsau.2c00271⟩. ⟨hal-04592516⟩
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