Pré-Publication, Document De Travail Année : 2024

Cortical sulci are regional neurodevelopmental biomarkers of schizophrenia diagnosis

Les sillons corticaux sont des biomarqueurs neuro-développementaux régionaux du diagnostic de la schizophrénie

Résumé

The human cortical brain is folded and made of bumps called gyri, separated by grooves called sulci. Folding is highly variable among individuals, and making sense of this variability has been a long-standing goal. Part of this variability can be described by clinically relevant parameters. Here, we learn to predict a mental disorder with a likely neurodevelopmental imprint---schizophrenia---from the cortical folds by using as volume inputs cortical skeletons, which are negative casts of the brain. We are looking for local folding descriptors, not global ones; thus, we scatter the learning over 24 sulcal bilateral regions on the two hemispheres and apply an ensemble method to each region. We found significant correlations between cortical folding and schizophrenia in the precentral, temporal, and occipital regions and the collateral fissure.

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Dates et versions

hal-04592457 , version 1 (29-05-2024)

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  • HAL Id : hal-04592457 , version 1

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Aymeric Gaudin, Pierre Auriau, Edouard Duchesnay, Denis Riviere, Joel Chavas, et al.. Cortical sulci are regional neurodevelopmental biomarkers of schizophrenia diagnosis. 2024. ⟨hal-04592457⟩
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