Urine concentration impairment in sickle cell anemia: genuine nephrogenic diabetes insipidus or osmotic diuresis? - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue American Journal of Physiology. Renal Physiology Année : 2024

Urine concentration impairment in sickle cell anemia: genuine nephrogenic diabetes insipidus or osmotic diuresis?

Résumé

The urine concentration impairment in sickle cell anemia is an osmotic diuresis related to an impaired renal medullary gradient leading to an ADH plateau effect. The fasting plasma ADH was high in the context of a basic state of close-to-maximal urine concentration probably driven by short nephrons maintaining a cortex-outer medullary gradient (about 400 milliosmoles). The patients had a low daily osmoles intake without evidence of thirst dysregulation so no one experienced polyuria.

Dates et versions

hal-04589874 , version 1 (27-05-2024)

Identifiants

Citer

Quentin de Berny, Camille Saint-Jacques, Aline Santin, Sarah Mattioni, Olivier Steichen, et al.. Urine concentration impairment in sickle cell anemia: genuine nephrogenic diabetes insipidus or osmotic diuresis?. American Journal of Physiology. Renal Physiology, 2024, 326 (2), pp.F278-F284. ⟨10.1152/ajprenal.00313.2023⟩. ⟨hal-04589874⟩
12 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More