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Chapitre D'ouvrage Année : 2011

Seroprevalence of Leishmania infantum in a rural area of Senegal: analysis of risk factors involved in transmission to humans

Babacar Faye
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Massila Wagué Senghor
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Abdoul Aziz Niang
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Souleymane Diedhiou
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Oumar Konaté
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Michel Mainack Dione
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Sandra Mellul
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Romy Knecht
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Pascal Delaunay
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Pierre Marty
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Oumar Gaye
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Résumé

Whereas Leishmania infantum, the agent of visceral leishmaniasis (VL), is well known in North Africa, very limited data exist on its spread in West Africa, where mainly cutaneous leishmaniasis has been widely reported. Nevertheless, dogs infected with L. infantum were recently found in the Mont Rolland District in Senegal. To provide a better understanding of L. infantum epidemiology in this area, clinical and serological surveys were carried out to determine the seroprevalence of L. infantum-specific antibodies in the human population. In parallel, an analysis of environmental and individual factors associated with Leishmania antigen seropositivity was conducted to identify potential risk factors for exposure. Although no cases of VL were detected within this study, a large part of the population (73/315; 23%) was exposed to infection, with a strong age effect (being >40 years old increased the risk of being seropositive). Moreover, the presence of Nebedaye trees (Moringa oleifera) and infected dogs in the household were factors increasing the risk of exposure in household members. These results may provide important information to identify the still unknown sandfly species involved in transmission.

Dates et versions

hal-04589271 , version 1 (27-05-2024)

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Babacar Faye, Bruno Bucheton, Anne-Laure Bañuls, Massila Wagué Senghor, Abdoul Aziz Niang, et al.. Seroprevalence of Leishmania infantum in a rural area of Senegal: analysis of risk factors involved in transmission to humans. Seroprevalence of Leishmania infantum in a rural area of Senegal: analysis of risk factors involved in transmission to humans, 105 (6), Wiley, pp.333-340, 2011, ⟨10.1016/j.trstmh.2011.02.009⟩. ⟨hal-04589271⟩
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