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Article Dans Une Revue ChemistryEurope Année : 2024

Synthesis of Peptides by Reactive Extrusion. Application to the Continuous and Solventless Preparation of Aspartame.

Résumé

The solventless synthesis of peptides from unactivated amino acids was optimized in a twin-screw extruder (TSE). The general method enabled the preparation of dipeptides and tripeptides with no epimerization. This flow mechanochemistry approach was applied to the synthesis of aspartame, a synthetic dipeptide, prepared in a continuous mode on large scale and with high productivity.
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hal-04578699 , version 1 (17-05-2024)

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Tharwat Mohy El‐dine, Matthieu Lavayssiere, Hélène Adihou, Gilles Subra, Thomas‐xavier Métro, et al.. Synthesis of Peptides by Reactive Extrusion. Application to the Continuous and Solventless Preparation of Aspartame.. ChemistryEurope, 2024, pp.e202400007. ⟨10.1002/ceur.202400007⟩. ⟨hal-04578699⟩
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