Generation of a healthy heavy smoker patient-derived induced pluripotent stem cell line UHOMi007-A from peripheral blood mononuclear cells - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Stem Cell Research Année : 2024

Generation of a healthy heavy smoker patient-derived induced pluripotent stem cell line UHOMi007-A from peripheral blood mononuclear cells

Résumé

Human pluripotent stem cells (hiPSC) represent a unique opportunity to model lung development and chronic bronchial diseases. We generated a hiPSC line from a highly characterized healthy heavy smoker male donor free from emphysema or tobacco related disease. Peripheral blood mononuclear cells (PBMCs) were reprogrammed using integration-free Sendai virus. The cell line had normal karyotype, expressed pluripotency hallmarks, and differentiated into the three primary germ layers. The reported UHOMi007-A iPSC line may be used as a control to model lung development, study human chronic bronchial diseases and drug testing.
Fichier principal
Vignette du fichier
2024 Ahmed et al., Generation of.pdf (493.36 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04577714 , version 1 (19-05-2024)

Identifiants

Citer

Engi Ahmed, Mathieu Fieldès, Chloé Bourguignon, Joffrey Mianné, Aurélie Petit, et al.. Generation of a healthy heavy smoker patient-derived induced pluripotent stem cell line UHOMi007-A from peripheral blood mononuclear cells. Stem Cell Research, 2024, 77, pp.103437. ⟨10.1016/j.scr.2024.103437⟩. ⟨hal-04577714⟩
13 Consultations
1 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More