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Article Dans Une Revue IEEE Transactions on Radiation and Plasma Medical Sciences Année : 2024

A High-Resolution Portable Gamma-Camera for Estimation of Absorbed Dose in Molecular Radiotherapy

Résumé

Molecular radiotherapy is a treatment modality that requires personalized dosimetry for efficient treatment and reduced toxicity. Current clinical imaging systems and miniaturized gamma-cameras lack the necessary features for this task. In this article, we present the design and optimization of a mobile gamma-camera with a 10×10 cm2 field of view tailored for quantitative imaging during 131I therapy of thyroid diseases. The camera uses a monolithic 10×10×1 cm3 CeBr3 scintillator coupled to a 16×16 SiPMs array and commercial electronics. It exhibits high imaging performance with an intrinsic spatial resolution (SR) of 1.15-mm FWHM, an energy resolution of 8% FWHM at 356 keV and negligible deadtime up to 150 kcps. Images are reconstructed in real time using a convolutional neural network. The manufacturing method of tungsten collimators and shielding was optimized using laser 3-D printing to achieve an effective density of 97% that of bulk tungsten. Their geometry was adjusted with Monte-Carlo simulations in order to reduce septal penetration and scattering and optimize the signal-to-noise ratio at short times after treatment administration. Two high-energy parallel-hole collimators with high sensitivity or very high SR were designed for treatment planning and post-treatment control. The fully operational gamma-camera will soon be clinically assessed.
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Origine : Publication financée par une institution
Licence : CC BY - Paternité

Dates et versions

hal-04574743 , version 1 (14-05-2024)

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Paternité

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T Bossis, M.-A Verdier, C Trigila, L Pinot, F Bouvet, et al.. A High-Resolution Portable Gamma-Camera for Estimation of Absorbed Dose in Molecular Radiotherapy. IEEE Transactions on Radiation and Plasma Medical Sciences, 2024, 8 (5), pp.556-570. ⟨10.1109/trpms.2024.3376826⟩. ⟨hal-04574743⟩
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