Respirable crystalline silica and lung cancer in community-based studies: impact of job-exposure matrix specifications on exposure–response relationships - Archive ouverte HAL Access content directly
Journal Articles Scandinavian Journal of Work, Environment and Health Year : 2024

Respirable crystalline silica and lung cancer in community-based studies: impact of job-exposure matrix specifications on exposure–response relationships

Johan Ohlander
Lützen Portengen
Domenico Cavallo
Andrea Cattaneo
Enrica Migliori
  • Function : Author
Lorenzo Richiardi
Nils Plato
  • Function : Author
Dario Consonni
Neil E Caporaso
Jack Siemiatycki
Per Gustavsson
Wolfgang Ahrens
Hermann Pohlabeln
David Zaridze
Jolanta Lissowska Lissowska
John K Field K Field
John Mclaughlin
Paul Demers
Tamás Pándics
  • Function : Author
Francesco Forastiere
Eleonora Fabianova
Lenka Foretova
Vladimir Janout
Dana Mates
Thomas Brüning
Thomas Behrens
Ann Olsson
Susan Peters

Abstract

OBJECTIVES: The quantitative job-exposure matrix SYN-JEM consists of various dimensions: job-specific estimates, region-specific estimates, and prior expert ratings of jobs by the semi-quantitative DOM-JEM. We analyzed the effect of different JEM dimensions on the exposure–response relationships between occupational silica exposure and lung cancer risk to investigate how these variations influence estimates of exposure by a quantitative JEM and associated health endpoints. METHODS: Using SYN-JEM, and alternative SYN-JEM specifications with varying dimensions included, cumulative silica exposure estimates were assigned to 16 901 lung cancer cases and 20 965 controls pooled from 14 international community-based case-control studies. Exposure–response relationships based on SYN-JEM and alternative SYN-JEM specifications were analyzed using regression analyses (by quartiles and log-transformed continuous silica exposure) and generalized additive models (GAM), adjusted for age, sex, study, cigarette pack-years, time since quitting smoking, and ever employment in occupations with established lung cancer risk. RESULTS: SYN-JEM and alternative specifications generated overall elevated and similar lung cancer odds ratios ranging from 1.13 (1st quartile) to 1.50 (4th quartile). In the categorical and log-linear analyses SYN-JEM with all dimensions included yielded the best model fit, and exclusion of job-specific estimates from SYN-JEM yielded the poorest model fit. Additionally, GAM showed the poorest model fit when excluding job-specific estimates. CONCLUSION: The established exposure–response relationship between occupational silica exposure and lung cancer was marginally influenced by varying the dimensions of SYN-JEM. Optimized modelling of exposure–response relationships will be obtained when incorporating all relevant dimensions, namely prior rating, job, time, and region. Quantitative job-specific estimates appeared to be the most prominent dimension for this general population JEM.
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Dates and versions

hal-04574417 , version 1 (14-05-2024)

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Johan Ohlander, Hans Kromhout, Roel C.H. Vermeulen, Lützen Portengen, Benjamin Kendzia, et al.. Respirable crystalline silica and lung cancer in community-based studies: impact of job-exposure matrix specifications on exposure–response relationships. Scandinavian Journal of Work, Environment and Health, 2024, 50 (3), pp.178-186. ⟨10.5271/sjweh.4140⟩. ⟨hal-04574417⟩
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