Overcoming Solubility Challenges: Liposomal isoCoQ‐Carbazole as a Promising Anti‐Tumor Agent for Inoperable and Radiation‐Insensitive cancers - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue ChemBioChem Année : 2024

Overcoming Solubility Challenges: Liposomal isoCoQ‐Carbazole as a Promising Anti‐Tumor Agent for Inoperable and Radiation‐Insensitive cancers

Résumé

Abstract This study evaluated the potential of iso CoQ‐Carbazole, a diheterocyclic analog of iso CA‐4, as an anti‐tumor agent. To overcome its low aqueous solubility, liposomes were developed as a delivery system for the compound. In vitro experiments showed that loaded liposomes exhibited similar activity to the free form on multiple human tumor cell lines. In vivo experiments using a palliative intratumoral injection chemotherapy approach further demonstrated that iso CoQ‐Carbazole loaded liposomes significantly reduced tumor growth in a CA‐4‐resistant HT29 cell model, without inducing any observable toxicity or weight loss in the treated mice. These findings suggest that liposomal iso CoQ‐Carbazole may hold promise as a potential therapeutic agent for the treatment of inoperable, radiation‐insensitive cancers.

Dates et versions

hal-04569859 , version 1 (06-05-2024)

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Diana Lamaa, Catherine Cailleau, Juliette Vergnaud, Julie Mougin, Jérôme Bignon, et al.. Overcoming Solubility Challenges: Liposomal isoCoQ‐Carbazole as a Promising Anti‐Tumor Agent for Inoperable and Radiation‐Insensitive cancers. ChemBioChem, 2024, ⟨10.1002/cbic.202400062⟩. ⟨hal-04569859⟩
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