The Iranian Zagros is a remarkable zone to study Middle and Upper Palaeolithic human occupations and Tang-e Shikan (Arsanjan) is a strategic cave site which archaeological evidence can be taken as a proxy for the southeast portion. Micromammals have been extensively used as palaeoecological indicators and here we use the assemblage from Tang-e Shikan to infer the landscape and environment that framed and arguably triggered cultural change. A thorough taphonomic analysis was undertaken prior to any interpretation. Fourteen taxa have been identified: two “insectivores” s.l., nine rodents, two lagomorphs, and unidentified chiropterans. The remains would be the digestion by-products of a category 5 opportunistic predator: either an avian raptor or a mammalian carnivore. Our results show that shrubland and grassland dominated the distribution of habitats in the area during the Middle Palaeolithic (MP), followed by moderate rocky, desert, and steppe components, and sparse patches of woodland. The younger period of the MP occupation (NMP: ~55-45 ka BP) would be somewhat wetter than the older period (OMP: ~70-55 ka BP). Within a general environmental stability, slight changes between OMP and NMP are reasonably correlated with a shift in certain cultural patterns, as the use of a water reservoir and a stone drainage system during the OMP or the increase of hunting and moderate change in lithic technology and raw material acquisition during the NMP. Our environmental inferences are further supported by palynological data and match a regional trend towards wetter habitats in moving from the MP to the present.