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Article Dans Une Revue International Journal of Infectious Diseases Année : 2024

HIV-1 Tat is present in the serum of people living with HIV-1 despite viral suppression

La protéine Tat du VIH-1 est présente dans les sera des personnes vivant avec le VIH malgré la thérapie antirétrovirale

Résumé

Objectives: Despite successful human immunodeficiency virus (HIV) control with combination antiretro- viral therapy (cART), individuals with HIV still face health risks, including cancers, cardiovascular and neurocognitive diseases. An HIV protein, Tat, is potentially involved in these HIV-related diseases. Previ- ous studies demonstrated circulating Tat in the blood of untreated people with HIV. Here, we measured Tat levels in the serum of cART-treated people with HIV to examine the effect of cART on Tat production. Methods: Serum samples from 63 HIV-positive and 20 HIV-seronegative individuals were analyzed using an ELISA assay that detected Tat concentrations above 2.5 ng/mL. Results: Among HIV-positive individuals, the Tat level ranged from 0 to 14 ng/mL. 25.4% (16 out of 63) exceeded the 2.5 ng/mL cut-off, with a median HIV Tat level of 4.518 [3.329-8.120] ng/mL. No correlation was revealed between Tat levels and CD4 + T cell counts, serum HIV RNA, p24 antigen, or anti-Tat levels. Conclusions: Despite cART, circulating HIV Tat persists and may contribute to HIV-related diseases. This emphasizes the need for further research on
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Dates et versions

hal-04558712 , version 1 (25-04-2024)

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Citer

Anna Shmakova, Ivan Tsimailo, Yana Kozhevnikova, Laurence Gérard, David Boutboul, et al.. HIV-1 Tat is present in the serum of people living with HIV-1 despite viral suppression. International Journal of Infectious Diseases, 2024, 142, pp.106994. ⟨10.1016/j.ijid.2024.106994⟩. ⟨hal-04558712⟩
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