Inclusion-body myositis associated with Sjögren's disease: clinical characteristics and comparison with other Sjögren-associated myositis. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Rheumatology Année : 2024

Inclusion-body myositis associated with Sjögren's disease: clinical characteristics and comparison with other Sjögren-associated myositis.

Quentin Astouati
  • Fonction : Auteur
Thomas Machet
  • Fonction : Auteur
Camille Houssais
  • Fonction : Auteur
Jean-Baptiste Noury
  • Fonction : Auteur
Yves Allenbach
  • Fonction : Auteur
Laure Gallay
  • Fonction : Auteur
Baptiste Quere
  • Fonction : Auteur
Florence Assan
  • Fonction : Auteur
Olivier Benveniste
  • Fonction : Auteur
Jonathan Broner
  • Fonction : Auteur
Pierre Duffau
  • Fonction : Auteur
Alexandra Espitia
  • Fonction : Auteur
Anne Grasland
  • Fonction : Auteur
Gilles Hayem
  • Fonction : Auteur
Véronique Le Guern
  • Fonction : Auteur
Nihal Martis
  • Fonction : Auteur
Kuberaka Mariampillai
  • Fonction : Auteur
Gaëtane Nocturne
  • Fonction : Auteur
Xavier Mariette
Denis Mulleman
  • Fonction : Auteur
Valérie Devauchelle-Pensec
  • Fonction : Auteur
Aurore Collet
  • Fonction : Auteur
David Launay
  • Fonction : Auteur
Eric Hachulla
Divi Cornec
  • Fonction : Auteur
Dewi Guellec
  • Fonction : Auteur
Sébastien Sanges
  • Fonction : Auteur

Résumé

Objectives To describe the characteristics of patients with Sjögren’s disease (SjD) and inclusion-body myositis (IBM), and how they compare to SjD patients with other inflammatory myopathies (IM). Methods Patients were retrospectively recruited from 13 French centres and included if they met the ACR/EULAR criteria for SjD and for IM. They were categorized as SjD-IBM if sub-criteria for IBM were met, or as SjD-other IM if not. Results SjD-IBM patients (n = 22) were mostly females (86%), with a median [Q1; Q3] age of 54 [38.5; 64] years at SjD diagnosis, and 62 [46.5; 70] years at first IBM symptoms. Although most patients displayed glandular and immunological abnormalities, additional extra-glandular manifestations were uncommon, resulting in moderate disease activity at SjD diagnosis (ESSDAI 5.5 [1; 7.8]). Classic IBM features were frequent, such as progressive symptom onset (59%), asymmetrical (27%) and distal (32%) involvements, dysphagia (41%), low CPK (386.5 [221.8; 670.5] UI/l) and CRP (3.0 [3; 8.5] mg/l) levels. Immunosuppressants were reported as efficient in 55% of cases. Compared with SjD-IBM patients, SjD patients with other IM (n = 50) were significantly younger, displayed more frequent additional extra-glandular disease, higher ESSDAI score (11 [3; 30]), shorter delay between SjD diagnosis and myositis onset (0 [−0.5; 26]), more frequent CPK values over 1000 UI/l (36%), and less frequent classic IBM features. Conclusion IBM can occur in SjD patients, with muscle features reminiscent of classic sporadic IBM characteristics, but mostly affecting women. In SjD patients with muscle involvement, extra-glandular manifestations, high ESSDAI score, elevated CPK values and shorter delay after SjD diagnosis plead against IBM.
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Dates et versions

hal-04547645 , version 1 (15-04-2024)

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Quentin Astouati, Thomas Machet, Camille Houssais, Jean-Baptiste Noury, Yves Allenbach, et al.. Inclusion-body myositis associated with Sjögren's disease: clinical characteristics and comparison with other Sjögren-associated myositis.. Rheumatology, 2024, in press, ⟨10.1093/rheumatology/keae129⟩. ⟨hal-04547645⟩

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