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Article Dans Une Revue Rheumatology international Année : 2024

Breakthrough SARS-CoV-2 infection and disease flares in patients with rheumatoid arthritis: result from COVAD e-survey study.

Cristiana Sieiro Santos
  • Fonction : Auteur
Jun-Peng Chen
  • Fonction : Auteur
Elena Nikiphorou
  • Fonction : Auteur
Chi-Wei Tseng
  • Fonction : Auteur
Carlos Enrique Toro Gutiérrez
  • Fonction : Auteur
Ai Lyn Tan
  • Fonction : Auteur
Arvind Nune
  • Fonction : Auteur
Esha Kadam
  • Fonction : Auteur
Masataka Kuwana
  • Fonction : Auteur
Jessica Day
  • Fonction : Auteur
Sreoshy Saha
  • Fonction : Auteur
Tsvetelina Velikova
  • Fonction : Auteur
James B Lilleker
  • Fonction : Auteur
Carlo V Caballero-Uribe
  • Fonction : Auteur
Parikshit Sen
  • Fonction : Auteur
Hector Chinoy
  • Fonction : Auteur
Rohit Aggarwal
  • Fonction : Auteur
Vikas Agarwal
  • Fonction : Auteur
Latika Gupta
  • Fonction : Auteur
Yi-Ming Chen
  • Fonction : Auteur

Résumé

COVID-19 has been suggested as a possible trigger of disease flares in patients with rheumatoid arthritis (RA). However, factors associated with disease flares remain unknown. This study aimed to identify factors associated with breakthrough infection (BIs) and disease flares in patients with RA following COVID-19. We analysed data from RA patients who participated in the COVID-19 vaccination in autoimmune diseases (COVAD) study. Demographic data, patient-reported outcomes, comorbidities, pharmacologic treatment and details regarding disease flares were extracted from the COVAD database. Factors associated with disease flare-ups were determined by multivariate logistic regression analysis. The analysis comprised 1928 patients with RA who participated in the COVAD study. Younger age, Caucasian ethnicity, comorbidities with obstructive chronic pulmonary disease and asthma were associated with COVID-19 breakthrough infection. Moreover, younger age (odds ratio (OR): 0.98, 95% CI 0.96-0.99, p < 0.001), ethnicity other than Asian, past history of tuberculosis (OR: 3.80, 95% CI 1.12-12.94, p = 0.033), treatment with methotrexate (OR: 2.55, 95% CI: 1.56-4.17, p < 0.001), poor global physical health (OR: 1.07, 95% CI 1.00-1.15, p = 0.044) and mental health (OR: 0.91, 95% CI 0.87-0.95, p < 0.001) were independent factors associated disease flares in patients with RA. Our study highlights the impact of socio-demographic factors, clinical characteristics and mental health on disease flares in patients with RA. These insights may help determine relevant strategies to proactively manage RA patients at risk of flares.
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Dates et versions

hal-04547644 , version 1 (15-04-2024)

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Citer

Cristiana Sieiro Santos, Jun-Peng Chen, Elena Nikiphorou, Chi-Wei Tseng, Carlos Enrique Toro Gutiérrez, et al.. Breakthrough SARS-CoV-2 infection and disease flares in patients with rheumatoid arthritis: result from COVAD e-survey study.. Rheumatology international, 2024, 44 (5), pp.805-817. ⟨10.1007/s00296-024-05542-3⟩. ⟨hal-04547644⟩

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