[68Ga]Ga-FAPI-46 synthesis on a GAIA® module system: thorough study of the automated radiolabeling reaction conditions - Archive ouverte HAL Access content directly
Journal Articles Applied Radiation and Isotopes Year : 2024

[68Ga]Ga-FAPI-46 synthesis on a GAIA® module system: thorough study of the automated radiolabeling reaction conditions

Abstract

The influence of several parameters involved in the 68Ga radiolabeling of FAPI-46 was studied at the scale of the automated reaction. Among the buffers tested, HEPES 0.3 M pH 4 allowed both high radiochemical purity (RCP) and radiochemical yield (RCY), without prepurification of 68Ga but after final purification of [68Ga]Ga-FAPI-46 on a C18 cartridge. A longer reaction time did not show significant benefit on the RCP, while higher loads of FAPI-46 and gentisic acid as anti-radiolysis compound allowed better RCY.
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Dates and versions

hal-04544439 , version 1 (15-04-2024)

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Léa Rubira, Charlotte Donzé, Juliette Fouillet, Benjamin Algudo, Pierre Olivier Kotzki, et al.. [68Ga]Ga-FAPI-46 synthesis on a GAIA® module system: thorough study of the automated radiolabeling reaction conditions. Applied Radiation and Isotopes, 2024, 206, pp.111211. ⟨10.1016/j.apradiso.2024.111211⟩. ⟨hal-04544439⟩
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