Article Dans Une Revue Marine Pollution Bulletin Année : 2024

Dioxins and furans maternal transfer: A study of breast milk and cord serum levels among Lebanese mothers and associations with newborn anthropometric measurements

Maya Mahfouz
  • Fonction : Auteur
  • PersonId : 1374121
Ramzi Finan
  • Fonction : Auteur
  • PersonId : 1374124
Georges Abi-Tayeh
  • Fonction : Auteur
  • PersonId : 1374125
Mohamad Meslimani
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  • PersonId : 1374126
Ghada Moussa
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  • PersonId : 1374127
Nada Chahrour
  • Fonction : Auteur
  • PersonId : 1374128
Camille Osseiran
  • Fonction : Auteur
  • PersonId : 1374129
Farouk Skaiki
  • Fonction : Auteur
  • PersonId : 1374130

Résumé

Dioxins and furans (PCDD/Fs) are anthropogenic pollutants that persist in the environment for long years, bioaccumulating in food & contaminating humans. In pregnancy, they can transfer through the placenta and reach the fetus, which negatively affects fetal growth. They can also reach newborns through breastfeeding. In this study, we focused on this critical subpopulation and identified the presence of PCDD/Fs among pregnant women in breast milk (n = 41) and cord serum (n = 49); we assessed the correlation between different matrices, evaluated the predictors and associations with newborn anthropometric measurements. Over 70.7 % of PCDD/Fs were detected in breast milk and 46.9–55.1 % in cord serum. Cord/maternal serum and breast milk to maternal serum ratios were > 1 with a significant positive Spearman correlation (0.669–0.729). Breast milk & maternal serum PCDD/Fs were associated inversely with age and positively with red meat intake. Cord serum PCDD/Fs were inversely associated with pre-pregnancy weight loss and passive smoking. Parity and gestational weight gain showed positive associations with Z-scores at birth. Z-score differences showed negative and positive associations with passive smoking and pre-pregnancy BMI respectively.

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Dates et versions

hal-04542683 , version 1 (11-04-2024)

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Yara Mahfouz, Mireille Harmouche-Karaki, Joseph Matta, Maya Mahfouz, Pascale Salameh, et al.. Dioxins and furans maternal transfer: A study of breast milk and cord serum levels among Lebanese mothers and associations with newborn anthropometric measurements. Marine Pollution Bulletin, 2024, 199, pp.116032. ⟨10.1016/j.marpolbul.2024.116032⟩. ⟨hal-04542683⟩
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