Using monthly data, this article examines the influence of Covid-19 on poverty, inequality, well-being, and environmental quality for a sample of 14 African economies from 2018 to 2020. To do so, we employ a GMM approach to look at the influence of the pandemic on achieving the SDGs in Africa. According to our empirical findings, the pandemic significantly impacts poverty and pollution levels. The results show also that the pandemic coefficient considerably influences the inequality proxy. Due to social exclusion and inequities, these economies must embrace an integrated socio-economic vision to overcome the multi-faceted pandemic externalities and build more resilient economies..