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Article Dans Une Revue Journal of Chemical Education Année : 2023

CR322: a Web-Based Board Game for Aiding Students in Reviewing Chemical Reactivity

Résumé

A series of novel N ‐triazolo‐benzene sulfonamides‐1,5‐benzodiazepines 9a–d and 10d were designed and prepared through the copper‐catalyzed azide alkyne cycloaddition click chemistry procedure, reacting the N 1 ‐propargyl‐1,5‐benzodiazepine 2 and the N 1 , N 5 ‐dipropargyl analog 6 with various benzene sulfonamide azides 8a–d . The synthesized compounds were found to show nanomolar affinity toward relevant isoforms of human carbonic anhydrase such as hCA I, II, IV, VII, IX, and XII. The divalent derivative 10d showed a particularly high inhibitory activity against all hCA isoforms when compared with acetazolamide, and showed potent multivalent effects, better than reported previously for divalent CA inhibitors.

Dates et versions

hal-04538566 , version 1 (09-04-2024)

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Citer

José Nunes da Silva Júnior, Antonio José Melo Leite Junior, Maria Clara Alexandre, Francisco Serra Oliveira Alexandre, Lucas Lima da Silva, et al.. CR322: a Web-Based Board Game for Aiding Students in Reviewing Chemical Reactivity. Journal of Chemical Education, 2023, 100 (12), pp.4866-4871. ⟨10.1021/acs.jchemed.3c00758⟩. ⟨hal-04538566⟩
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