Superelectrophilic Csp 3 –H bond fluorination of aliphatic amines in superacid: the striking role of ammonium–carbenium dications - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemical Communications Année : 2020

Superelectrophilic Csp 3 –H bond fluorination of aliphatic amines in superacid: the striking role of ammonium–carbenium dications

Résumé

The superacid-promoted electrophilic Csp3–H bond activation of aliphatic amines generates superelectrophilic species that can be subsequently fluorinated. Demonstrated by low-temperature in situ NMR experiments, the ammonium–carbenium dications, crucial for this reaction, can also react with C–H bonds opening future synthesis perspectives for this mode of activation.

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Chimie organique
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hal-04537283 , version 1 (16-04-2024)

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M. Artault, N. Mokhtari, T. Cantin, Agnès Martin-Mingot, Sébastien Thibaudeau. Superelectrophilic Csp 3 –H bond fluorination of aliphatic amines in superacid: the striking role of ammonium–carbenium dications. Chemical Communications, 2020, 56 (44), pp.5905-5908. ⟨10.1039/d0cc02081h⟩. ⟨hal-04537283⟩
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