Superelectrophilic Csp 3 –H bond fluorination of aliphatic amines in superacid: the striking role of ammonium–carbenium dications
Résumé
The superacid-promoted electrophilic Csp3–H bond activation of aliphatic amines generates superelectrophilic species that can be subsequently fluorinated. Demonstrated by low-temperature in situ NMR experiments, the ammonium–carbenium dications, crucial for this reaction, can also react with C–H bonds opening future synthesis perspectives for this mode of activation.
Domaines
Chimie organique
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