Animal Models of Chorioamnionitis: Considerations for Translational Medicine - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Biomedicines Année : 2022

Animal Models of Chorioamnionitis: Considerations for Translational Medicine

Margaux Digonnet
  • Fonction : Auteur
Antoine Giraud
Taghreed Ayash
  • Fonction : Auteur
Seline Vancolen
  • Fonction : Auteur
Mohamed Benharouga
Céline Chauleur
  • Fonction : Auteur
Guillaume Sébire
  • Fonction : Auteur

Résumé

Preterm birth is defined as any birth occurring before 37 completed weeks of gestation by the World Health Organization. Preterm birth is responsible for perinatal mortality and long-term neurological morbidity. Acute chorioamnionitis is observed in 70% of premature labor and is associated with a heavy burden of multiorgan morbidities in the offspring. Unfortunately, chorioamnionitis is still missing effective biomarkers and early placento- as well as feto-protective and curative treatments. This review summarizes recent advances in the understanding of the underlying mechanisms of chorioamnionitis and subsequent impacts on the pregnancy outcome, both during and beyond gestation. This review also describes relevant and current animal models of chorioamnionitis used to decipher associated mechanisms and develop much needed therapies. Improved knowledge of the pathophysiological mechanisms underpinning chorioamnionitis based on preclinical models is a mandatory step to identify early in utero diagnostic biomarkers and design novel anti-inflammatory interventions to improve both maternal and fetal outcomes.

Dates et versions

hal-04534297 , version 1 (05-04-2024)

Identifiants

Citer

Tiphaine Raia-Barjat, Margaux Digonnet, Antoine Giraud, Taghreed Ayash, Seline Vancolen, et al.. Animal Models of Chorioamnionitis: Considerations for Translational Medicine. Biomedicines, 2022, 10 (4), pp.811. ⟨10.3390/biomedicines10040811⟩. ⟨hal-04534297⟩
0 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More