EG-VEGF maternal levels predict spontaneous preterm birth in the second and third trimesters in pregnant women with risk factors for placenta-mediated complications - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Scientific Reports Année : 2023

EG-VEGF maternal levels predict spontaneous preterm birth in the second and third trimesters in pregnant women with risk factors for placenta-mediated complications

Tiphaine Raia-Barjat
  • Fonction : Auteur
Céline Chauleur
  • Fonction : Auteur
Constance Collet
  • Fonction : Auteur
Florence Rancon
  • Fonction : Auteur
Pascale Hoffmann
  • Fonction : Auteur
Morgane Desseux
  • Fonction : Auteur
Nicolas Lemaitre
  • Fonction : Auteur
Mohamed Benharouga
  • Fonction : Auteur
Antoine Giraud
  • Fonction : Auteur

Résumé

Abstract Prediction of spontaneous preterm birth in asymptomatic women remains a great challenge for the public health system. The aim of the study was to determine the informational value of EG-VEGF circulating levels for prediction of spontaneous preterm birth in the second and third trimesters in pregnant women at high risk for placenta-mediated complications. A prospective multicenter cohort study including 200 pregnant patients with five-serum sampling per patient. Women with spontaneous preterm birth have higher concentrations of serum EG-VEGF than uncomplicated patients at 24 weeks, 28 weeks and 32 weeks (p = 0.03, 0.02 and < 0.001). The areas under the curve reached 0.9 with 100% sensitivity at 32 weeks for the prediction of spontaneous preterm birth. Serum EG-VEGF concentrations could be considered as a reliable biomarker of spontaneous preterm birth in high-risk for placenta-mediated complications pregnant women.

Dates et versions

hal-04534247 , version 1 (05-04-2024)

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Citer

Tiphaine Raia-Barjat, Céline Chauleur, Constance Collet, Florence Rancon, Pascale Hoffmann, et al.. EG-VEGF maternal levels predict spontaneous preterm birth in the second and third trimesters in pregnant women with risk factors for placenta-mediated complications. Scientific Reports, 2023, 13 (1), pp.19921. ⟨10.1038/s41598-023-46883-6⟩. ⟨hal-04534247⟩
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