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Article Dans Une Revue Clinical Immunology Année : 2024

Type I interferon associated epistasis may contribute to early disease-onset and high disease activity in juvenile-onset lupus

Résumé

Pathologic type I interferon (T1IFN) expression is a key feature in systemic lupus erythematosus (SLE) that associates with disease activity. When compared to adult-onset disease, juvenile-onset (j)SLE is characterized by increased disease activity and damage, which likely relates to increased genetic burden. To identify T1IFN-associated gene polymorphisms (TLR7, IRAK1, miR-3142/miR-146a, IRF5, IRF7, IFIH1, IRF8, TYK2, STAT4), identify long-range linkage disequilibrium and gene:gene interrelations, 319 jSLE patients were genotyped using panel sequencing. Coupling phenotypic quantitative trait loci (QTL) analysis identified 10 jSLE QTL that associated with young age at onset (<12 years; IRAK1 [rs1059702], TLR7 [rs3853839], IFIH1 [rs11891191, rs1990760, rs3747517], STAT4 [rs3021866], TYK2 [rs280501], IRF8 [rs1568391, rs6638]), global disease activity (SLEDAI-2 K >10; IFIH1 [rs1990760], STAT4 [rs3021866], IRF8 [rs903202, rs1568391, rs6638]), and mucocutaneous involvement (TLR7 [rs3853839], IFIH1 [rs11891191, rs1990760]). This study suggests T1IFN-associated polymorphisms and gene:gene interrelations in jSLE. Genotyping of jSLE patients may allow for individualized treatment and care.

Dates et versions

hal-04532026 , version 1 (04-04-2024)

Identifiants

Citer

Yves Renaudineau, Amandine Charras, Valentina Natoli, Mathieu Fusaro, Eve M.D. Smith, et al.. Type I interferon associated epistasis may contribute to early disease-onset and high disease activity in juvenile-onset lupus. Clinical Immunology, 2024, 262, pp.110194. ⟨10.1016/j.clim.2024.110194⟩. ⟨hal-04532026⟩
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