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Article Dans Une Revue Expert Opinion on Therapeutic Targets Année : 2023

Are tumour-associated carbonic anhydrases genuine therapeutic targets for photodynamic therapy?

Résumé

Photodynamic therapy (PDT) is a reactive oxygen species (ROS)-dependent treatment modality which has emerged as an alternative cancer therapy strategy. However, in solid tumors, the therapeutic efficacy of PDT is strongly reduced by hypoxia, a typical feature of many such tumors. The tumor-associated carbonic anhydrases IX (hCA IX) and XII (hCA XII), which are overexpressed under hypoxia are attractive, validated anticancer drug targets in solid tumors. Current challenges in therapeutic design of effective PDT systems aim to overcome the limitation of hypoxia by developing synergistic CA-targeted therapies combining photosensitizers and hCA IX/XII inhibitors.

Domaines

Chimie Cancer
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Dates et versions

hal-04530220 , version 1 (03-04-2024)

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Citer

Amina Merabti, Sébastien Richeter, Claudiu T Supuran, Sébastien Clement, Jean-Yves Winum. Are tumour-associated carbonic anhydrases genuine therapeutic targets for photodynamic therapy?. Expert Opinion on Therapeutic Targets, 2023, 27 (9), pp.817-826. ⟨10.1080/14728222.2023.2255380⟩. ⟨hal-04530220⟩
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