A lupeol derivative and other isolates with antiplasmodial activity from the stem root of Rauvolfia mannii Stapf. (Apocynaceae) - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Natural Product Research Année : 2024

A lupeol derivative and other isolates with antiplasmodial activity from the stem root of Rauvolfia mannii Stapf. (Apocynaceae)

Résumé

Rauvolfia mannii is a plant from western and eastern areas of African continent and is widely used in folk medicine for the treatment of various diseases including malaria. Herein, one previously undescribed acylated triterpene (1), together with five already published natural products (2-6) were removed from its roots. The chemical structures of these compounds were determined by spectroscopic and spectrometric means (NMR, HRESIMS, IR and UV). In addition to the isolated triterpenoids, components 5 and 6 are also newly reported from the genus Rauvolfia. Moreover, some constituents were further tested against the chloroquine-sensitive strain of P. falciparum (3D7). It has been found that 3 and 4 showed a moderate antiplasmodial activity with IC50 values of 46.25 and 39.79 µM respectively.

Domaines

Chimie
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mercredi 18 septembre 2024
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mercredi 18 septembre 2024
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Dates et versions

hal-04528886 , version 1 (17-04-2024)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Fred Alain Zoua, Daniela Ntomi Djipmegne, Mc Jesus Kinyok, Auguste Abouem À Zintchem, André Néhémie Bitombo, et al.. A lupeol derivative and other isolates with antiplasmodial activity from the stem root of Rauvolfia mannii Stapf. (Apocynaceae). Natural Product Research, 2024, ⟨10.1080/14786419.2024.2327623⟩. ⟨hal-04528886⟩
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