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Article Dans Une Revue European Journal of Dermatology Année : 2019

Origanum essential oils reduce the level of melanin in B16-F1 melanocytes

Résumé

BACKGROUND: Hyperpigmentation disorders are considered signs of skin aging and are esthetically unpleasant. Most active ingredients fighting against hyperpigmentation disorders are mostly targeting the tyrosinase activity. OBJECTIVE: In this article, we seek to study the effect of two Origanum essential oils (EO) on the melanogenic activity of MEL B16-F1 murine melanocytes. We also explore the effect of their main component, carvacrol, and propose a model for its anti-melanogenic activity. METHOD: MEL B16-F1 melanocytes were exposed to different concentrations of essential oils and of carvacrol. Inhibition of tyrosinase production and reduction of melanin production were determined by spectrophotometric measurements. RESULTS: Essential oils of Origanum syriacum and Origanum ehrenbergii showed a significant reduction in the melanin production by 14% and 17% respectively at 40µg mL-1. However, they did not show a significant effect on the intracellular tyrosinase production. Same effect was found with Carvacrol that showed a reduction in the melanin production by around 30% at 45 µg mL-1. CONCLUSION: Our results are in favor for an anti-melanogenic activity of the studied EO. We propose a mechanism for the inhibition of the tyrosinase activity that is based on the binding of carvacrol to tyrosinase that catalyzes its oxidation, preventing thus the oxidation of tyrosine and causing a deregulation in the melanogenesis pathway. This mechanism of competitive inhibition could be similar to the mechanism of action of hydroquinone.
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Dates et versions

hal-04528256 , version 1 (01-04-2024)

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Rindala El Khoury, Rime Michael-Jubeli, Joudi Bakar, Hani Dakroub, Toufic Rizk, et al.. Origanum essential oils reduce the level of melanin in B16-F1 melanocytes. European Journal of Dermatology, 2019, 29 (6), pp.596-602. ⟨10.1684/ejd.2019.3677⟩. ⟨hal-04528256⟩
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