Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases
Alice Huertas
(1)
,
Christophe Guignabert
(2, 3, 4)
,
Joan Barberà
,
Peter Bärtsch
(5)
,
Jahar Bhattacharya
,
Sunita Bhattacharya
,
Maria Bonsignore
(6)
,
Laurence Dewachter
(7)
,
Anh Tuan Dinh-Xuan
(8)
,
Peter Dorfmüller
(2, 3, 4)
,
Mark Gladwin
,
Marc Humbert
(9, 1)
,
Tom Kotsimbos
(10)
,
Theodoros Vassilakopoulos
(11)
,
Olivier Sanchez
(12)
,
Laurent Savale
(2, 3, 4)
,
Ugo Testa
(13)
,
Martin Wilkins
(14)
1
HPPIT -
Hypertension pulmonaire : physiopathologie et innovation thérapeutique
2 HPPIT - Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique
3 Université Paris-Saclay
4 Service d'Anesthésie et de Soins Intensifs [Bicêtre]
5 Heidelberg University Hospital [Heidelberg]
6 Università degli studi di Palermo - University of Palermo
7 ULB - Université libre de Bruxelles
8 Service de Physiologie Respiratoire, Hôpital Cochin, Université Paris Descartes, Paris
9 ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
10 Monash University [Melbourne]
11 NKUA - National and Kapodistrian University of Athens
12 IMRB - Institut Mondor de recherche biomédicale
13 Department of Haematology, Oncology and Molecular Medicine
14 Imperial College London
2 HPPIT - Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique
3 Université Paris-Saclay
4 Service d'Anesthésie et de Soins Intensifs [Bicêtre]
5 Heidelberg University Hospital [Heidelberg]
6 Università degli studi di Palermo - University of Palermo
7 ULB - Université libre de Bruxelles
8 Service de Physiologie Respiratoire, Hôpital Cochin, Université Paris Descartes, Paris
9 ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
10 Monash University [Melbourne]
11 NKUA - National and Kapodistrian University of Athens
12 IMRB - Institut Mondor de recherche biomédicale
13 Department of Haematology, Oncology and Molecular Medicine
14 Imperial College London
Alice Huertas
- Fonction : Auteur
- PersonId : 1322294
- ORCID : 0000-0001-8545-747X
Christophe Guignabert
- Fonction : Auteur
- PersonId : 184750
- IdHAL : christophe-guignabert
- ORCID : 0000-0002-8545-4452
- IdRef : 095316213
Joan Barberà
- Fonction : Auteur
Jahar Bhattacharya
- Fonction : Auteur
Sunita Bhattacharya
- Fonction : Auteur
Mark Gladwin
- Fonction : Auteur
Marc Humbert
- Fonction : Auteur
- PersonId : 756837
- ORCID : 0000-0003-0703-2892
- IdRef : 071559426
Résumé
The European Respiratory Society (ERS) Research Seminar entitled “Pulmonary vascular endothelium: orchestra conductor in respiratory diseases - highlights from basic research to therapy” brought together international experts in dysfunctional pulmonary endothelium, from basic science to translational medicine, to discuss several important aspects in acute and chronic lung diseases. This review will briefly sum up the different topics of discussion from this meeting which was held in Paris, France on October 27–28, 2016. It is important to consider that this paper does not address all aspects of endothelial dysfunction but focuses on specific themes such as: 1) the complex role of the pulmonary endothelium in orchestrating the host response in both health and disease (acute lung injury, chronic obstructive pulmonary disease, high-altitude pulmonary oedema and pulmonary hypertension); and 2) the potential value of dysfunctional pulmonary endothelium as a target for innovative therapies.