Risk factors for EUS-guided radiofrequency ablation adverse events in patients with pancreatic neoplasms: a large national French study (RAFPAN study) - Archive ouverte HAL
Article Dans Une Revue Gastrointestinal Endoscopy Année : 2023

Risk factors for EUS-guided radiofrequency ablation adverse events in patients with pancreatic neoplasms: a large national French study (RAFPAN study)

Bertrand Napoléon
  • Fonction : Auteur
Andrea Lisotti
  • Fonction : Auteur
Fabrice Caillol
  • Fonction : Auteur
Mohamed Gasmi
  • Fonction : Auteur
Philippe Ah-Soune
  • Fonction : Auteur
Arthur Belle
  • Fonction : Auteur
Antoine Charachon
  • Fonction : Auteur
Franck Cholet
  • Fonction : Auteur
Pierre-Yves Eyraud
  • Fonction : Auteur
Philippe Grandval
  • Fonction : Auteur
Jean-Michel Gonzalez
  • Fonction : Auteur
Stéphane Koch
  • Fonction : Auteur
Marc Le Rhun
  • Fonction : Auteur
Luigi Mangialavori
  • Fonction : Auteur
Nicolas Musquer
  • Fonction : Auteur
Maxime Palazzo
  • Fonction : Auteur
Laurent Poincloux
  • Fonction : Auteur
Jocelyn Privat
  • Fonction : Auteur
Adrien Sportes
  • Fonction : Auteur
Morgane Stouvenot
  • Fonction : Auteur
Clement Subtil
  • Fonction : Auteur
Lucie Thomassin
  • Fonction : Auteur
Geoffroy Vanbiervliet
  • Fonction : Auteur
Guillaume Vidal
  • Fonction : Auteur
Lucine Vuitton
  • Fonction : Auteur
Marc Giovannini
  • Fonction : Auteur
Marc Barthet
  • Fonction : Auteur

Résumé

Background and Aims EUS-guided radiofrequency ablation (EUS-RFA) has been described as a potentially curative option for solid and cystic pancreatic neoplasms. We aimed to assess the safety and efficacy of pancreatic EUS-RFA in a large study population. Methods A retrospective study retrieving all consecutive patients who underwent pancreatic EUS-RFA during 2019 and 2020 in France was conducted. Indication, procedural characteristics, early and late adverse events (AEs), and clinical outcomes were recorded. Risk factors for AEs and factors related to complete tumor ablation were assessed on univariate and multivariate analyses. Results One hundred patients (54% men, 64.8 ± 17.6 years old) affected by 104 neoplasms were included. Sixty-four neoplasms were neuroendocrine neoplasms (NENs), 23 were metastases, and 10 were intraductal papillary mucinous neoplasms with mural nodules. No procedure-related mortality was observed, and 22 AEs were reported. Proximity of pancreatic neoplasms (≤1 mm) to the main pancreatic duct was the only independent risk factor for AEs (odds ratio [OR), 4.10; 95% confidence interval [CI), 1.02-15.22; P = .04). Fifty-nine patients (60.2%) achieved a complete tumor response, 31 (31.6%) a partial response, and 9 (9.2%) achieved no response. On multivariate analysis, NENs (OR, 7.95; 95% CI, 1.66-51.79; P < .001) and neoplasm size <20 mm (OR, 5.26; 95% CI, 2.17-14.29; P < .001) were independently related to complete tumor ablation. Conclusions The results of this large study confirm an overall acceptable safety profile for pancreatic EUS-RFA. Close proximity (≤1 mm) to the main pancreatic duct represents an independent risk factor for AEs. Good clinical outcomes in terms of tumor ablation were observed, especially for small NENs.

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Dates et versions

hal-04525862 , version 1 (28-03-2024)

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Citer

Bertrand Napoléon, Andrea Lisotti, Fabrice Caillol, Mohamed Gasmi, Philippe Ah-Soune, et al.. Risk factors for EUS-guided radiofrequency ablation adverse events in patients with pancreatic neoplasms: a large national French study (RAFPAN study). Gastrointestinal Endoscopy, 2023, 98 (3), pp.392-399. ⟨10.1016/j.gie.2023.04.003⟩. ⟨hal-04525862⟩

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