Urban environment during pregnancy and childhood and white matter microstructure in preadolescence in two European birth cohorts - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Environmental Pollution Année : 2024

Urban environment during pregnancy and childhood and white matter microstructure in preadolescence in two European birth cohorts

Résumé

Growing evidence suggests that urban environment may influence cognition and behavior in children, but the underlying pollutant and neurobiological mechanisms are unclear. We evaluated the association of built environment and urban natural space indicators during pregnancy and childhood with brain white matter microstructure in preadolescents, and examined the potential mediating role of air pollution and road-traffic noise. We used data of the Generation R Study, a population-based birth cohort in Rotterdam, the Netherlands (n = 2725; 2002-2006) for the primary analyses. Replication of the main findings was attempted on an independent neuroimaging dataset from the PELAGIE birth cohort, France (n = 95; 2002-2006). We assessed exposures to 12 built environment and 4 urban natural spaces indicators from conception up to 9 years of age. We computed 2 white matter microstructure outcomes (i.e., average of fractional anisotropy (FA) and mean diffusivity (MD) from 12 white matte tracts) from diffusion tensor imaging data. Greater distance to the nearest major green space during pregnancy was associated with higher whole-brain FA (0.001 (95%CI 0.000; 0.002) per 7 m increase), and higher land use diversity during childhood was associated with lower whole-brain MD (-0.001 (95%CI -0.002; -0.000) per 0.12-point increase), with no evidence of mediation by air pollution nor road-traffic noise. Higher percentage of transport and lower surrounding greenness during pregnancy were associated with lower whole-brain FA, and road-traffic noise mediated 19% and 52% of these associations, respectively. We found estimates in the same direction in the PELAGIE cohort, although confidence intervals were larger and included the null. This study suggests an association between urban environment and white matter microstructure, mainly through road-traffic noise, indicating that greater access to green space nearby might promote white matter development.
Fichier principal
Vignette du fichier
1-s2.0-S0269749124003269-main.pdf (1.3 Mo) Télécharger le fichier
1-s2.0-S0269749124003269-mmc1.pdf (1.63 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-04517299 , version 1 (22-03-2024)

Licence

Paternité

Identifiants

Citer

Anne-Claire Binter, Laura Granés, Elise Bannier, Montserrat de Castro, Sami Petricola, et al.. Urban environment during pregnancy and childhood and white matter microstructure in preadolescence in two European birth cohorts. Environmental Pollution, 2024, 346, pp.123612. ⟨10.1016/j.envpol.2024.123612⟩. ⟨hal-04517299⟩
1 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More