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Article Dans Une Revue European Respiratory Journal Année : 2020

Understanding the pathophysiological mechanisms of cardiometabolic complications in obstructive sleep apnoea: towards personalised treatment approaches

Silke Ryan
Eoin Cummins
  • Fonction : Auteur
Ramon Farre
  • Fonction : Auteur
Alex Gileles-Hillel
  • Fonction : Auteur
Jonathan Jun
Henrik Oster
  • Fonction : Auteur
David Ray
  • Fonction : Auteur
Sirimon Reutrakul
  • Fonction : Auteur
Manuel Sanchez-De-La-Torre
  • Fonction : Auteur
Renaud Tamisier
Isaac Almendros

Résumé

In January 2019, a European Respiratory Society research seminar entitled “Targeting the detrimental effects of sleep disturbances and disorders” was held in Dublin, Ireland. It provided the opportunity to critically review the current evidence of pathophysiological responses of sleep disturbances, such as sleep deprivation, sleep fragmentation or circadian misalignment and of abnormalities in physiological gases such as oxygen and carbon dioxide, which occur frequently in respiratory conditions during sleep. A specific emphasis of the seminar was placed on the evaluation of the current state of knowledge of the pathophysiology of cardiovascular and metabolic diseases in obstructive sleep apnoea (OSA). Identification of the detailed mechanisms of these processes is of major importance to the field and this seminar offered an ideal platform to exchange knowledge, and to discuss pitfalls of current models and the design of future collaborative studies. In addition, we debated the limitations of current treatment strategies for cardiometabolic complications in OSA and discussed potentially valuable alternative approaches.

Dates et versions

hal-04510908 , version 1 (19-03-2024)

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Citer

Silke Ryan, Eoin Cummins, Ramon Farre, Alex Gileles-Hillel, Jonathan Jun, et al.. Understanding the pathophysiological mechanisms of cardiometabolic complications in obstructive sleep apnoea: towards personalised treatment approaches. European Respiratory Journal, 2020, 56 (2), pp.1902295. ⟨10.1183/13993003.02295-2019⟩. ⟨hal-04510908⟩

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